Ryan Murray's PhD Research Published in Nature Communications

KiraGen Bio is proud to announce that Ryan Murray, our Co-Founder and Chief Scientific Officer, has published his PhD thesis research in Nature Communications, one of the world’s leading scientific journals.

The study demonstrates that solid tumors suppress T cell function through multiple, overlapping, and non-redundant mechanisms rather than any single dominant pathway. This coordinated suppression helps explain why many single-target approaches have struggled to achieve durable responses in solid tumors.

These findings validate the core hypothesis behind KiraGen’s approach. Effective cell therapies for solid tumors must incorporate combinatorial modifications designed to match the complexity of the tumor microenvironment. As Ryan noted, “This dataset is only the tip of the iceberg, but it makes one thing clear. Many current single-strategy engineering approaches will not be enough on their own.”

KiraGen was founded to tackle this challenge directly. Congratulations to Ryan on this important milestone and on providing the field with a clearer picture of what effective solid tumor immunotherapy must contend with!

Read the full publication →