Programmable durability
for solid-tumor cell therapy.

Ready when patients need them.
Built to endure when tumors fight back.

Explore Our Science
A CAR-T cell inside noise-cancelling headphones as suppressive signals approach

The durability gap

In recurrent GBM, CAR-T can shrink tumors. Control often does not last.

Before CAR-T
After CAR-T
8 of 13 Radiographic regressions 1.9 months Median PFS
Bagley et al., Nature Medicine (NCT05168423).

WHAT DURABLE CONTROL REQUIRES

A response is only the beginning.

Durable control depends on all three.

Reach

Get to the tumor.

Recognize

See enough of the disease.

KiraGen's focus

Resist

Keep working when the tumor fights back.

Three suppressive signal streams meet muted receptors on an engineered T-cell membrane while active CAR signaling continues

Our approach to resistance

Noise cancellation for cell therapy.

We use multiplex gene editing to help CAR-T cells resist several suppressive routes at once.

The tumor keeps sending the signals. We change which ones the cell can hear.

Explore KiraGen

Backed by investors. Supported by disease foundations.

Investor backing

Disease foundation support